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English name: t-Boc-MP; t-Boc-MDMA
Alias: t-boc methamphetamine
Uses: a new raw material for methamphetamine
Properties: yellow crystalline powder
The company has first-class experimental equipment, new product research and preparation tE.Chnology. The new raw material of ice poison is t-boc methamphetamine, phenethylamine with t-Boc group on the amine [4,5,6]; t-boc methyl Amphetamine, t-BOC methamphetamine, T-boc is a form of methamphetamine. N-tert-butoxycarbonyl-MDMA (t-BOC-MDMA) is a MDMA which is a tert-butoxycarbonyl derivative.
Phenylalanine can also be reduced to amphetamine:
1. Step: Preparation of D-phenylalaninol: To a cold solution of LiBH 4 (1.32 g, 60.54 mmol) in THF (30 ml, freshly distilled from LiAlH 4) was added trimethylsilyl chloride (15.36 ml , 121.07 mmol). The ice / water bath was removed and the mixture was stirred at room temperature for 15 minutes. The mixture was re-cooled to 0 ° C and D-phenylalanine (5 g, 30.27 mmol) was added. The ice / water bath was removed and the reaction mixture was stirred overnight. The mixture was cooled again to 0 ° C, and MeOH (45 ml) was added dropwise, followed by 2.5 M aqueous NaOH (25 ml). The mixture was evaporated in vacuo and the residue was extracted with chloroform (5x). The combined extracts were dried (Na2SO4), filtered, and evaporated in vacuo to give 4.55 g (99%) of the product as a white crystalline solid. Melting point: 88-90 ° C.
2. Step: Nt-Boc-D-phenylalaninol: To a stirred, cooled (0 ° C) solution of D-phenylalaninol (5 g, 33.1 mmol) in 85 ml of chloroform is added solid di-tert-butyl dicarbonate. Ester (7.22 g, 33.1 mmol). The solution was stirred at 0 ° C for 0.5 h and then at room temperature overnight. The solution was washed with 20% phosphoric acid, saturated NaHCO3 solution and saturated NaCl solution, then dried (Na2CO3) and evaporated to dryness under reduced pressure. The obtained solid was rE.Crystallized from a hot hexane / ethyl acetate mixture to obtain 7.48 g (95%) of a white fibrous crystalline product. Melting point: 96 ° C.
3. Step: Preparation of (1R) -1-benzyl-2-iodoethylcarbamic acid tert-butyl ester: 2.92 g of polymer-supported triphenylphosphine (8.75 mmol) was stirred to To a suspension in water DCM (35 ml), 2.22 g of iodine (8.75 mmol) was added, followed by 0.65 g of imidazole (9.55 mmol). The mixture was allowed to warm to ambient temperature, and after 0.5 hours a solution of 1.26 g (3.98 mmol) of Nt-Boc-D-phenylalaninol in DCM (15 ml) was added dropwise. The mixture was then heated at reflux for 2 hours. The cooled mixture was then filtered, and the solution was washed with dilute aqueous Na2S2O3 and water, dried (Na2SO4), and evaporated to a white crystalline solid. The residue was passed through a short silica gel column (3: 2, EtOAc: hexane) to give the pure product, which was rE.Crystallized from hot hexane to give 1.09 g of the product (88%) as white crystals. Melting point: 121-122 ° C
4. Step: (1S) tert-butyl-1-methyl-2-phenylethylcarbamate: Stir 1.00 g (2.77 mmol) of iodo compound in anhydrous THF (20 ml) at -15 ° C. While in the solution, 3.04 ml (3.04 mmol) of a 1.0 M N-SelE.Ctride solution (in THF) was added dropwise through a syringe. The mixture was heated to 5 ° C over 1.5 hours. The progress of the reaction was monitored by TLC (4: 1 hexane: EtOAc). The solution was cooled to 0 ° C and the reaction was quenched by slowly adding 1.3 ml of water. A solution made by combining 15 ml of H 2 O, 1.0 g of K 2 CO 3 and 2.6 ml of 30% H 2 O 2 was then added dropwise. The reaction mixture was stirred at ambient temperature for 1 h. The THF was evaporated under reduced pressure, and the product was extracted from the residue with DCM (3x). The organic extract was dried (Na2SO4) and the solvent was evaporated to give a white solid.
5. Step: (1S) -1-methyl-2-phenylethylamine hydrochloride: To stirred (0 ° C) cooled (0 ° C) tert-butyl carbamate (2.59g, 11.0mmol) To a solution in DCM (20 ml) was added trifluoroacetic acid (5 ml). The solution was stirred at ambient temperature for 18 hours. The volatile components were reduced under reduced pressure, and the residue was treated with water (10 ml), chloroform (15 ml) and a NaOH solution (2 ml, 50%). The mixture was shaken and the layers were separated. The aqueous layer was extracted with chloroform (5 ×), and the combined organic extracts were dried over Na 2 SO 4 and filtered. 6 ml of a 1.0 M HCl solution (in Et 2 O) was added thereto, and the solvent was removed to obtain a yellow solid. This was rE.Crystallized from hot hexane / acetone to give a white needle-like crystal product, 1.34 g (91%).
扣扣σσ：１４３-０４１-７７５７
Synthetic cannabinoid pharmaceutical intermediates:ADB-BUTINACA;MDMB-BUTINACA;SGT-78,CUMYL-4CN-BINACA,CUMYL-CYBINACA;AKB48CH,STS-135;5F-AEB,5F-EMB-PINACA,5-fluoro-EMB-PINACA;4CN-ADB,4CN-MDMB-PINACA;4F-ADB,4F-MDMB-PINACA;MMB-022;5-CL-ADB-A,Nonos.5-cl-adb-a;MPHP-2201;AB-CHMFUPPYCA;5C-AKB48;SGT-263,CUMYL-5F-P7AICA;4-AcO-EPT,4-ACO-DMT;4-AcO-DET;4-AcO-MALT;4-HO-McPT;4-AcO-DMT;4-HO-MET;DPT .HCL;PAGOCLONE;ETIZOLAM;METHYL-CLONAZEPAM;FLUALPRAZOLAM;NITRAZOLAM;BROMAZOLAM;Ro5-4864;3-HYDROXYPHENAZEPAM;vx-809,Lumacaftor;;PRE-084;A-PCYP,α-pcyp;MDPEP;NDH;BK-BBDP,BK-BUTYL-K;4F-MPH.HCL,4-FMPH;4-FEA;ISOPROPYLPHENIDATE,IPH,IPPD;3-HO-PCE;2-FDCK,2-F-2'-Oxo-PCM;3-HO-PCP;BOD;25E-NBOH.HCL,NBOH-2C-E,2C-E;25I-NBOH;2F-VIMINOL;2-METHYL-AP-237;Piperidinohton;O-DSMT,O-Desmethyltramadol;4-HO-MIPT;4F-MPH;5-MeO-MIPT;5C-AKB48;5F-ABICA POWDER;5F-ADB;5F-AKB48;5F-MN24;5F-PB22;5F-PCN;AB-CHMINACA;AB-FUBINACA;AB-PINACA;ADB-FUBINACA;AM-2201 POWDER;BB-22 POWDER;BLACK TAR HEROIN;BUY BMK OIL ONLINE;;BUY HASH OIL;FUB-AKB48;FUNKY BUDDHA BLEND;KING COBRA;MAM-2201;MDMB CHMCZCA;MDMB CHMINACA;MMB-CHMINACA;NM-2201 POWDER;PB-22 POWDER;SKY HIGH BLEND;THJ-018;THJ-2201;SGT-24;JWH-369;JWH-368;
CAS,Excellent quality and dedicated service：
☎TeL:156-3108-7078;
6740-85-8,0-Chlorphenyl Cyclopentyl Ketone;
111982-50-4,2FDCK,2F-DCK;
111982-49-1,F-Ketamine;
33817-09-3,51062-14-7,51-57-0,Methamphetamine;
96332-84-2,1-Phenyl-2-aminopropane;
299-42-3,Ephedrine;
25394-33-6,chloroephedrine;
25394-24-5,1-Chloro-N-methyl-1-phenylpropan-2-amine hydrochloride;
30572-91-9;
6740-88-1,33795-24-3,1867-66-9,Ketamine;
185913-79-5,C17H22ClNO3,SR-121463A;
90717-16-1,Hydroxylimine;
14838-15-4,Norpseudoephedrine;
110925-64-9,Chloroephedrine HCL;
33817-09-3,Methamphetamine,MDA;
2114-00-3,2-Bromopropiophenone;
23022-83-5,1-Bromo-1-phenylacetone;
103-79-7,Phenylacetone;
4468-48-8,120065-76-1,2-Phenylacetoacetonitrile;
69610-10-2,MDMA;
74698-47-8,LSD,Lysergide;
4764-17-4,MDA;
4F-ADB;4F-MDMB-PINACA;
1715016-75-3,5F-ADB,5F-MDMB-PINACA;
209414-07-3,AM 678,JWH018;
335161-24-5,AM2201,AM-2201;
1715016-78-6,MDMB-CHMICA;
1715016-76-4,AMB-FUBINACA,5F-MDMB-2201,FUB-AMB;
1445583-51-6,ADB-FUBINACA,FUB-ADB;
72242-03-6,5F-UR144;
1364933-54-9,5-fluoro UR-144,5-F-UR144;
1782099-36-8,XLR11;
1971007-92-7,MMB-FUBINACA;
1400742-13-3,5F-AKB48,AKB-48F,5F-APINACA,AKB-48F,35FAKB-48;
5650-44-2,486459-03-4,152610-69-0,66514-93-0,Methcathinon;
24622-62-6,MDPV,MDPK,Methylenedioxypyrovalerone;
14530-33-7,α-PVP,Α-PVP,mpvp;
5485-65-4,α-PVP,4C-PVP,M-PVP,9FPVP;
1112937-64-0,Ethylone;
1225843-86-6,4-CMC;
1451-82-7,Propiophenone,1-Propanone;
437-38-7,Fentanyl;
21409-26-7,4-ANPP;
39742-60-4,NPP;
990-73-8,Fentanyl citrate;
59708-52-0,Carfentani;
1445583-48-1,5F-ADBICA;
100001-00-1,1P-LSD;
286834-84-2,Benzo Fury,6-APB;
1354631-79-0,6-MAPB;
1364933-55-0,5-MAPB,THJ-018;THJ-2201;5F-MDMB;EG-018;
1354631-77-8,5-MAPB;
N9,U-47700;
82657-23-6,U-48800;
67579-76-4,U-49900;
7726-95-6,Bromine,dibromin;
25188-98-1,PMMA;
1400742-17-7,PB-22;
4021-34-5,5-MeO-DiPT;
919797-19-6,2C-I-NBOMe,25I-NBOMe;
90-84-6,Amfepramone,diethylpropion;
Oxycodone,Morphinan-6-one;
122-09-8,phentermine;
458-24-2,Fenfluramine;
99294-93-6,ZolpidemTartrateTablets;
43200-80-2,Zopiclone;
2078-54-8,PropofolInje.ctio,Disopprofol,Propofol,Diprivan;
2011-67-8,Nimetazepam,Erimin5,2H-1,Elimin;
1622-62-4,Flunitrazepam;
51753-57-2,Phenazepam;
58-08-2,Caffeine;
82-58-6,Lysergic acid diethylamine,LSD;
113-45-1,Methylphenidate,Ritalin;
adderall,Adla;
68693-11-8,Modafinil;
67-66-3,Chloroform;
5470-06-4,PB-22;
13605-48-6,PMK,methyl,glycidate;
915-30-0,Diphenoxylate;
139755-83-2,sildenafil;
244195-31-1,4-Fluorobutyrfentanyl;
13605-48-6,4676-39-5,Pmk glycidate,MDP 2 P;
1892-80-4,3736-08-1,Fenetyllin,Winetallinee,jihadi pill,Captagon;
96096-55-8,5-MeO-MiPT;
1631074-54-8,SGT-78,SGT78;
22374-89-6,Amphetamine;
1971007-88-1,5FMDMB-2201,5F-MDMB-2201,MDDPV;
837112-21-7,NM-2201,GH-2201,CBL-2201,MPHP-2201,5C-AKB48;
8492312-32-2,BK-EBDP,6-EAPB,bkh4,bkedbp;
174418-82-7,7-Hydroxy Mitragynine,Kratom;
802855-66-9,Eutylone,BK-EBDB,bk-ebdp,bk-ebdb,eu;
1334921-74-2,t-boc methamphetamine;t-boc-mp,T-Boc-mdma;
t-boc,t-Butylcarbonyl;
146659-37-2,RTI-126;
3695-38-3,EN-018;
1354631-24-5,MAM-2201,MAM2201;
185913-78-4,SR121463;
THJ-018,THG-2201,5F-MDMB;
1801552-01-1,THJ-2201;
175591-23-8,Tapentadol;
695213-59-3,SDB-006,bk-epdp;
96096-54-7,5-MEO-MIPT;
15532-75-9,TFTP AKOS BBS-00003586;
860027-50-5,2759-28-6,1-Benzylpiperazine,BZP;
16015-69-3,TFMPP;
889493212,5cak48,5C-AKB48;
99918-43-1,N-PHENYLPIPERIDIN-4-AMINE DIHYDROCHLORIDE;
4433-77-6,BMK;
1801552-03-3,5F-AMB,5F-AMB-PINACA,5F-MMBPINACA,5-Fluoro-AMB;
301254-20-5,5F-ABPINACA,5F-AB-PINACA;
965212-01-2,5F-ADB-PINACA;
Synthetic Cannabinoids,SCS;
35211-10-0,Norketamine;